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Chemically, Polyisoprene condoms are very similar to latex condoms. But it will not give you allergic reactions that latex is known to give. If you are allergic to latex, then you can try Polyisoprene condoms, as you and your partner may not find any big difference in terms of sensation.

As with latex, even oil based lubricants should not be used with Polyisporene condoms as well.